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Platelet Glycoprotein Ia C807TBoth blood platelets and genetics contribute to the development of acute ischemic arterial diseases. Only few studies have been performed for platelet GPla (integrin alpha2), but there is support for the 807 T/C polymorphism of GPIa as risk factor in younger age groups. Isolated reports suggest other platelet polymorphisms (GPIIb, FcgammaRIIa, P-selectin, alpha2 adrenergic receptor, transforming growth factor [TGF]beta) are risk factors for arterial disease or produce a prothrombotic phenotype. Platelet glycoprotein polymorphisms should be added to the list of genetic risk factors for arterial thrombosis, particularly in younger patients and women (1-4).References 1. Bray PF. Platelet glycoprotein polymorphisms as risk factors for thrombosis. Curr Opin Hematol 2000 Sep;7(5):284-9 2. Reiner AP et al. Genetic variants of platelet glycoprotein receptors and risk of stroke in young women. Stroke 2000 Jul;31(7):1628-33 <Abstract/Full Text> 3. Santoso S et al. Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients. Blood 1999 Apr 15;93(8):2449-53 <Abstract/Full Text> 4. Kunicki TJ et al. Hereditary variation in platelet integrin a2b1density is associated with two silent polymorphism in the a2 gene coding sequence. Blood 89:1939, 1997 <Abstract/Full Text> |